Artificial intelligence for the evaluation of profiles, trajectories and management of vulnerability in health: COVID-19, frailty of the elderly and cancer
Differential Diagnosis of Parkinsonian syndromes using artifical intelligence and multimodal MRI
The main objectives of the projects are : i) to improve the accuracy of automated classification techniques for the differenciation of parkinsonian subjectts, ii) to determine the added value of MRI and automated classification in the early stages of parkinsonian syndromes, iii) to extend our classification methods to other forms of parkinsonian syndrome. To make these techniques applicable in the clinic, we will propose new deep learning approaches capable of simultaneously extracting relevant biomarkers and providing diagnostic categorization at the individual level.
Parkinsonian syndrome of neurodegenerative origin is most often caused by Parkinson's disease. More rarely, it is said to be atypical, belonging to the spectrum of tauopathies (progressive supranuclear palsy and corticobasal degeneration) or synucleinopathies (multisystematic atrophy, and dementia with Lewy bodies). Clinical differentiation of Parkinsonian syndromes is often difficult, especially in the early stages of the disease. Magnetic resonance imaging (MRI) provides specific biomarkers that can be used to train and validate artificial intelligence algorithms to accurately classify parkinsonian subjects.
Artificial intelligence methods (machine learning) for automatic patient classification and biomarkers extraction from multimodal brain MRI images.
AP-HP, Inria, CNRS, Inserm, Sorbonne Université, Institut du Cerveau