SENEC (university hospital federation)

Understanding SENEsCence to improve life course health trajectory
Underway

Collaboration type

Research structure

Main objectives

SENEC aims to develop a common multi-scale and multidisciplinary approach to chronic diseases (red blood cell, neurodegenerative, pulmonary, cardiovascular and metabolic) with a particular focus on:
- the links between the pathogenesis and progression of these diseases and the load of cellular senescence
- the trans-generational transmission of premature aging.

Based on patient cohorts, biological and imaging collections and preclinical models, SENEC aims to
- Assess the impact of cellular senescence among other confounding factors (environmental, social and genetic) in the prediction of organ damage
- Study the intergenerational inheritance of premature aging in clinical and preclinical models of aging (focus on obesity and sickle cell disease) and predict health trajectories over the life course
- Establish the framework for clinical trials of interventions targeting aging

Members

INSERM, INRIA, AP-HP, INRA, CNRS, ENSAM, UPEC, Université Paris Saclay, Fondation PremUp, ANSES Partenaires privés : OPALE , MITOLOGICS , GREENPHARMA S.A.S , METABRAIN RESEARCH , SANOFI, CHIC

Other projects

COVIPREDS

Description

US Caractérisation et prédiction de la survenue de formes graves ou létales du COVID-19 à partir des données issues de l’EDS de l’AP-HP

Names of partners involved
AP-HP, Inria & Centrale Supélec

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