The program is based on the assembly of elementary bricks (hepatic organoids, vascular and biliary networks built separately) integrated on a scaffold support (with guidance by in silico modeling) with study of the functionality of the constructions in vitro after implantation in animal models. It is declined in two applications: construction (1) of an external bio-artificial liver for the treatment of patients with liver failure and (2) of a liver-on-a-chip model for the study of drug metabolism and in vitro toxicology in microfluidic systems, of which prototypes will be available for phase I/II clinical trials and industrialization (final steps carried out in GMP) in order to end up with (3) a transplantable liver.