innovations in Liver tissue engineering

Main objectives

The program is based on the assembly of elementary bricks (hepatic organoids, vascular and biliary networks built separately) integrated on a scaffold support (with guidance by in silico modeling) with study of the functionality of the constructions in vitro after implantation in animal models. It is declined in two applications: construction (1) of an external bio-artificial liver for the treatment of patients with liver failure and (2) of a liver-on-a-chip model for the study of drug metabolism and in vitro toxicology in microfluidic systems, of which prototypes will be available for phase I/II clinical trials and industrialization (final steps carried out in GMP) in order to end up with (3) a transplantable liver.
© INRIA / BANG (illustration)


Aenitis, AP-HP, Biopredic, CEA, IFBF, CNRS, Cellenion, ENS Paris-Saclay, Inria, Inserm, Institut Pasteur, Universités de Nantes, Paris-Diderot, Paris-Saclay, Sorbonne Paris Nord, de Tokyo, UTC

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Other projects



US Caractérisation et prédiction de la survenue de formes graves ou létales du COVID-19 à partir des données issues de l’EDS de l’AP-HP

Names of partners involved
AP-HP, Inria & Centrale Supélec

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