Artificial intelligence for the evaluation of profiles, trajectories and management of vulnerability in health: COVID-19, frailty of the elderly and cancer
innovations in Liver tissue engineering
The program is based on the assembly of elementary bricks (hepatic organoids, vascular and biliary networks built separately) integrated on a scaffold support (with guidance by in silico modeling) with study of the functionality of the constructions in vitro after implantation in animal models. It is declined in two applications: construction (1) of an external bio-artificial liver for the treatment of patients with liver failure and (2) of a liver-on-a-chip model for the study of drug metabolism and in vitro toxicology in microfluidic systems, of which prototypes will be available for phase I/II clinical trials and industrialization (final steps carried out in GMP) in order to end up with (3) a transplantable liver.
© INRIA / BANG (illustration)
Aenitis, AP-HP, Biopredic, CEA, IFBF, CNRS, Cellenion, ENS Paris-Saclay, Inria, Inserm, Institut Pasteur, Universités de Nantes, Paris-Diderot, Paris-Saclay, Sorbonne Paris Nord, de Tokyo, UTC