Artificial intelligence for the evaluation of profiles, trajectories and management of vulnerability in health: COVID-19, frailty of the elderly and cancer
iLite
innovations in Liver tissue engineering
Underway
Main objectives
The program is based on the assembly of elementary bricks (hepatic organoids, vascular and biliary networks built separately) integrated on a scaffold support (with guidance by in silico modeling) with study of the functionality of the constructions in vitro after implantation in animal models. It is declined in two applications: construction (1) of an external bio-artificial liver for the treatment of patients with liver failure and (2) of a liver-on-a-chip model for the study of drug metabolism and in vitro toxicology in microfluidic systems, of which prototypes will be available for phase I/II clinical trials and industrialization (final steps carried out in GMP) in order to end up with (3) a transplantable liver.

© INRIA / BANG (illustration)
Members
Aenitis, AP-HP, Biopredic, CEA, IFBF, CNRS, Cellenion, ENS Paris-Saclay, Inria, Inserm, Institut Pasteur, Universités de Nantes, Paris-Diderot, Paris-Saclay, Sorbonne Paris Nord, de Tokyo, UTC
Useful links
https://ifbf-institute.org/projets/ilite-innovation-in-liver-tissue-engineering-2016-2022
Other projects
Description
Learning a deep representation of patient records for event prediction and patient segmentation
Names of partners involved
AP-HP, Inria